Non-steric-zipper models for pathogenic α-synuclein conformers
نویسندگان
چکیده
منابع مشابه
Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
BACKGROUND α-Synuclein (αS) is the major component of several types of brain inclusions including Lewy bodies, a hallmark of Parkinson's disease. Aberrant aggregation of αS also is associated with cellular demise in multiple neurologic disorders collectively referred to as synucleinopathies. Recent studies demonstrate the induction of αS pathology by a single intracerebral injection of exogenou...
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Parkinson's disease (PD) is not only characterized by motor disturbances but also, by cognitive, sensory, psychiatric and autonomic dysfunction. It has been proposed that some of these symptoms might be related to the widespread pathology of α-synuclein (α-syn) aggregation in different nuclei of the central and peripheral nervous system. However, the pathogenic formation of α-syn aggregates in ...
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Parkinson disease (PD) is an incurable neurodegenerative disorder linked to the misfolding and aggregation of α-synuclein protein in dying neurons. Several molecular features of α-synuclein that appear to contribute to its properties are the familial mutant E46K, serine phosphorylation, and hydrophobic residues, but their exact role is unclear. I used two yeast models to examine how the E46K mu...
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α-Synucleinopathies are neurodegenerative disorders that are characterized by progressive decline of motor and non-motor dysfunctions. α-Synuclein (αS) has been shown to play a causative role in neurodegeneration, but the pathogenic mechanisms are still unclear. Thus, there are no radical therapies that can halt or reverse the disease's progression. β-Synuclein (βS), the non-amyloidogenic homol...
متن کاملBrain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice.
Aggregation and neuron-to-neuron transmission are attributes of α-synuclein relevant to its pathogenetic role in human synucleinopathies such as Parkinson's disease. Intraparenchymal injections of fibrillar α-synuclein trigger widespread propagation of amyloidogenic protein species via mechanisms that require expression of endogenous α-synuclein and, possibly, its structural corruption by misfo...
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ژورنال
عنوان ژورنال: APL Bioengineering
سال: 2018
ISSN: 2473-2877
DOI: 10.1063/1.5023460